Although researchers nonetheless have no idea exactly what triggers the uncoating of VP7, they do know that it seems to occur when the virus senses a lowered focus of calcium in its atmosphere. To get a closer have a look at how antibodies latch onto VP7 and נערות ליווי בבת ים neutralize the virus, Harrison and his colleagues used x-ray crystallography to study the molecular architecture of VP7 in the grasp of a fragment of the antibody. X-ray crystallography is a powerful device for “seeing” the orientation of atoms and the distances separating them throughout the molecules. Before Harrison’s crew might use x-ray crystallography, however, they first needed to crystallize VP7 in complex with the antibody fragment. Only after that step was completed, may they transfer on to bombarding those crystallized proteins with x-rays. Computers helped seize the diffraction patterns that emerged as the x-rays scattered from the crystal lattice. By rotating the crystallized protein complexes by means of a number of exposures, the researchers could record sufficient information to calculate three-dimensional fashions, which uncovered the underlying structure of VP7 and נערות ליווי בבת ים the antibody fragment.

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